. 2022 Dec 19;66(1):149–169. doi: 10.1021/acs.jmedchem.2c01658

Table 7. PK Parameters of RMC-5552 38 and RMC-6272 40 in Mice at 1 mg/kg via IP Administration^a.

compounds	T_max (h)	C_max (ng/mL)	C_max (μM)	AUC_last (ng/mL × h)	AUC_last (μM × h)	t_1/2 (h)
38 RMC-5552	2.0 ± 0.0	5667 ± 1106	3.19 ± 0.62	46 089 ± 5320	25.9 ± 3.0	4.8 ± 0.4
40 RMC-6272	2.3 ± 1.5	1793 ± 186	0.97 ± 0.10	16 169 ± 2293	8.7 ± 1.2	3.8 ± 0.6

Male Balb/c mice (mean ± SD, n = 3); vehicle = transcutol/solutol HS15/H₂O 5%/5%/90% (v,w,v)

Table 7. PK Parameters of RMC-5552 38 and RMC-6272 40 in Mice at 1 mg/kg via IP Administrationa.