| S/N |
Differentiating features |
Amelanotic melanoma |
Large cell lymphoma |
Poorly differentiated carcinoma |
| 1 |
Symptoms |
Tender lesion over hard palate, erythematous flat lesion |
Rapidly growing mass causing obstructive symptoms |
Exophytic/ ulcerated mass |
| 2 |
Microscopy |
Epithelioid/fusiform/polymorphous cells infiltrating |
Complete effacement of parent tissue, centroblastic/immunoblastic/anaplastic |
Poorly differentiated tumor nests infiltration |
| 3 |
On Immunohistochemistry |
Positive for S100 (97%), HMB45 (85%), Melan A (71%) |
Positive B cell for-CD20, CD79a, PAX8 Others: MUM1,,BCL6, CD10 |
Positive for CK5/CK6, p63, p16 |
