Fig. 2.

Anti-inflammatory effects of cannabinoids (1–5) isolated from hemp roots. Inflammasome activation in THP-cells was induced by the stimulation with LPS-nigericin. Effects of 1–5 (at 50 µM) on the production of pro-inflammatory cytokines including IL-1β (A) and TNF-α (B). Data are presented as means ± standard deviation from samples with three replicated experiments (n = 3). Statistical analysis was performed with a one-way analysis of variance with multiple comparisons and the significance was noted as: ***p < 0.001, ****p < 0.0001 vs. the model (LPS-nigericin stimulated) group and ####p < 0.0001 vs. the control group