Fig. 3.

Anti-inflammatory effects of non-cannabinoids isolated from hemp roots (11, 13, 19, 20, 25, 29, and 32). Inflammasome activation in THP-cells was induced by the stimulation with LPS-nigericin. Effects of 11, 13, 19, 20, 25, 29, and 32 (at 50 µM) on the production of pro-inflammatory cytokines including IL-1β (A) and TNF-α (B). Data are presented as means ± standard deviation from samples with three replicated experiments (n = 3). Statistical analysis was performed with a one-way analysis of variance with multiple comparisons and the significance was noted as: *p < 0.005, ****p < 0.0001 vs. the model (LPS-nigericin stimulated) group and ####p < 0.0001 vs. the control group