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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Pharmacol Ther. 2022 Dec 17;241:108334. doi: 10.1016/j.pharmthera.2022.108334

Figure 1. Domain structure of the human DNMT and TET family proteins.

Figure 1.

(A) Conserved domains of DNMTs showing DMAP1 binding, RFTS, CXXC, BAH, PWWP, ADD, and MTase domains. Canonical DNMTs, which are DNMT1, DNMT3A, and DNMT3B, retaining catalytic domain MTase, however, non-canonical DNMTs, which are DNMT2 and DNMT3L, showing truncated and loss of catalytic domain. (B) Conserved domains of TETs showing CXXC and catalytic domains.