(A) Conserved domains of DNMTs showing DMAP1 binding, RFTS, CXXC, BAH, PWWP, ADD, and MTase domains. Canonical DNMTs, which are DNMT1, DNMT3A, and DNMT3B, retaining catalytic domain MTase, however, non-canonical DNMTs, which are DNMT2 and DNMT3L, showing truncated and loss of catalytic domain. (B) Conserved domains of TETs showing CXXC and catalytic domains.