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. 2023 Jan 4;6(1):1–11. doi: 10.1021/acsptsci.2c00197

Figure 2.

Figure 2

In vivo pharmacokinetic profile of ARN23746. (A) Mouse brain PK profile of ARN23746 following IP administration at 10 mg/kg. (B) Mouse plasmatic PK profile of ARN23746 following IP administration at 10 mg/kg. (C) Observed and calculated PK parameters of ARN23746 after IP administration. (D) Mouse plasmatic PK profile of ARN23746 following PO administration at 10 mg/kg. (E) Mouse brain PK profile of ARN23746 following PO administration at 10 mg/kg. (F) Observed and calculated PK parameters of ARN23746 after PO administration. Data represent mean ± SEM from 3 independent experiments.