Figure 11.

Structures of SARS-CoV-2 3CL^pro in complex with cyclohexyl-containing compounds 15d and 17d. Panels (A, B) are Fo-Fc polder omit maps (green mesh) contoured at 3σ, and hydrogen bond interactions are shown in panels (C, D). The compounds are as follows15d (A, C) and 17d (B, D). Superposition of 15d (gray) and 17d (coral) showing the position of the cyclohexyl rings in the S4 subsite. Surface representation with residues colored yellow (nonpolar), cyan (polar), and white (weakly polar) (E).