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Superposition of the SARS-CoV-2 3CLpro inhibitor bound structures containing m-fluoro and m-chloro aryl rings. Differences in the orientation of 5c (cyan, fluoro) and 6c (coral, chloro) (A). Alternate view of panel A showing the conformational change in the SARS-CoV-2 3CLpro loop spanning Gln 189-Gly 195 associated with 5c (magenta) and 6c (light green) (B).
