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. 2022 Dec 30;6(1):151–170. doi: 10.1021/acsptsci.2c00202

Figure 11.

Figure 11

ML321 has low cataleptic potential in C57BL/6J mice compared to haloperidol in the horizontal bar test. Baseline responses were recorded and then separate groups of C57BL/6J mice were injected with either vehicle (Veh) or the indicated doses of haloperidol (HAL) or ML321 (ML). Mice were tested 60 min later for catalepsy. The latency for a mouse to remove its paws from the bar was recorded as an index of catalepsy (60 second maximum time). A RMANOVA observed the main effects of time [F(1,72) = 85.874, p < 0.001] and treatment [F(7,72) =35.542, p < 0.001] as well as the time by treatment interaction [F(7,72) = 37.267, p < 0.001] to be significant. The data are presented as means ± SEMs. N = 10 mice/group. *p < 0.05, baseline vs 60 min; ^p < 0.05, 1 mg/kg HAL vs 0.01 and 0.1 mg/kg HAL, and all doses of ML; +p < 0.05, 10 mg/kg HAL vs 0.01 and 0.1 mg/kg HAL, and all doses of ML.