Fig. 1.

representative photomicrograph of H&E stain of liver tissue of normal control group (A): showing central vein (cv) surrounded with normal hepatocytes (arrow head) arranged in cords and separated by blood sinusoids (s); HFD+T2DM group (B): liver tissue showing dilated central veins (CV), NASH with marked micro (wavy arrow) and macro (bifid arrow) -steatosis in hepatocytes with ballooning degeneration (short arrow) along with inflammatory cellular infiltration (if); HFD+T2DM+Fasudil group (C): showing mildly dilated central veins (cv) and partially restoring the normal architecture of the liver where most hepatocytes show normal vesicular nuclei (arrow head), but still showing mild fatty changes in the form of macrosteatosis in hepatocytes (bifid arrow) and hydrobic degeneration (short arrow) (H&E ×400).