Fig. 7.

Frailty tools fail to predict underlying pathology. Following endpoint assessments, the mice were culled and a post-mortem inspection was performed. To estimate the condition, mice with identified tumors, enlarged organs, or other serious abnormalities were scored a 1, minor abnormalities a 2, and otherwise unremarkable a 3. The scoring system was first applied to compare SED versus HIIT mice (A). Next, the score system was correlated to each of the frailty assessment tools, however, (B) shows a representative comparison as correlation was not observed with any of the frailty tools.