Table 1.
Physical performance assessments in SED and HIIT mice. 24-month female mice were assessed using a battery of physical performance behavioral tests and then were administered an 8-week HIIT regimen (n = 14) or remained sedentary (n = 11) for 8 weeks. Baseline and endpoint performance was then compared within groups using a paired student’s t-test, while the changes from baseline to endpoint were compared using an unpaired student’s T-test (p < 0.05 indicated in bold). We did not identify any significant differences between groups at either time point.
| SED | HIIT | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Assessment | Baseline | Endpoint | p | Baseline | Endpoint | p | SED Delta | HIIT Delta | p |
| Uphill treadmill (m/min) | 16.9 ± 3.8 | 16.5 ± 5.0 | 0.7713 | 14.6 ± 4.3 | 17.6 ± 5.5 | 0.0025 | −0.5 ± 5.0 | 3.0 ± 3.0 | 0.0441 |
| Flat treadmill (min) | 19.9 ± 10.0 | 25.3 ± 7.3 | 0.1510 | 18.2 ± 10.5 | 31.8 ± 13.7 | < 0.0001 | 5.3 ± 11.4 | 13.6 ± 7.5 | 0.0114 |
| Grip strength (N) | 2.07 ± 0.37 | 1.73 ± 0.19 | 0.0037 | 2.00 ± 0.31 | 1.87 ± 0.30 | 0.2534 | −0.34 ± 0.30 | −0.13 ± 0.40 | 0.1636 |
| Grip str/BW (mN/g) | 59.8 ± 13.3 | 51.1 ± 13.4 | 0.0031 | 54.4 ± 20.6 | 49.1 ± 11.8 | 0.1812 | −8.8 ± 7.4 | −5.4 ± 14.2 | 0.4869 |
| Gait speed (cm/s) | 29.8 ± 6.2 | 32.0 ± 6.1 | 0.2604 | 28.0 ± 5.2 | 32.7 ± 5.5 | 0.0280 | 2.2 ± 5.9 | 4.7 ± 7.0 | 0.3409 |
| Rotarod latency (s) | 105.8 ± 39.8 | 125.2 ± 46.5 | 0.0892 | 103.8 ± 65.5 | 122.1 ± 61.7 | 0.3601 | 19.4 ± 34.1 | 18.3 ± 72.2 | 0.9648 |
| Grid hang latency (s) | 27.1 ± 35.4 | 32.6 ± 43.3 | 0.2711 | 38.6 ± 72.9 | 46.2 ± 85.1 | 0.2640 | 5.5 ± 15.8 | 7.6 ± 24.5 | 0.8078 |
| Grid hang impulse (N.s) | 8.1 ± 8.7 | 8.5 ± 9.5 | 0.8177 | 10.7 ± 17.3 | 12.1 ± 20.6 | 0.4705 | 0.4 ± 5.6 | 1.4 ± 7.0 | 0.7050 |
| Activity wheels (km/d) | 0.33 ± 0.21 | 0.47 ± 0.17 | 0.0006 | 0.24 ± 0.24 | 0.48 ± 0.33 | 0.0023 | 0.15 ± 0.24 | 0.24 ± 0.27 | 0.4255 |
| Open field dis. (km) | 12.1 ± 8.3 | 22.7 ± 9.7 | 0.0004 | 12.7 ± 8.6 | 24.4 ± 10.0 | 0.0022 | 10.5 ± 6.1 | 11.7 ± 11.6 | 0.7698 |
| OF crossings | 64.1 ± 51.7 | 104.2 ± 45.9 | 0.0046 | 61.2 ± 44.3 | 114.0 ± 46.7 | 0.0050 | 40.1 ± 33.9 | 52.8 ± 58.5 | 0.5456 |
| OF rearings | 39.9 ± 28.9 | 79.2 ± 50.5 | 0.0006 | 50.2 ± 67.3 | 73.9 ± 50.5 | 0.1009 | 39.3 ± 24.1 | 23.6 ± 50.1 | 0.3719 |
| OF velocity (cm/s) | 11.1 ± 1.3 | 12.8 ± 1.0 | 0.0010 | 11.1 ± 1.6 | 12.1 ± 1.4 | 0.0283 | 1.6 ± 1.1 | 0.9 ± 1.4 | 0.2188 |