Table 3.

Comparison of physical performance in surviving versus non-surviving mice. Baseline parameters were compared in SED (n = 11) and mice that died before endpoint assessments (n=7). Additionally, assessment values were correlated to the number of days survived from baseline in the group of deceased mice.

	SED	Deceased	p	Correlation (r) to days survived
Body weight (g)	39.2 ± 11.8	44.8 ± 20.3	0.4657	0.67
Weight loss 1 wk. prior	−0.5 ± 2.4	−5.3 ± 7.5	0.0667	0.68
Weight loss 1 mo. prior	−9.9 ± 6.2	−14.9 ± 8.0	0.1496	−0.01
Body temperature (°C)	32.3 ± 0.6	32.1 ± 1.0	0.6536	−0.84*
Uphill treadmill (m/min)	14.9 ± 3.5	13.4 ± 5.8	0.5060	−0.21
Flat treadmill (min)	18.1 ± 8.1	14.2 ± 11.9	0.4211	0.24
Grip strength (N)	2.10 ± 0.40	1.80 ± 0.30	0.1306	0.41
Gait speed (cm/s)	31.0 ± 5.9	22.7 ± 6.8	0.0260 *	−0.66
Rotarod latency (s)	105.8 ± 39.8	80.8 ± 76.8	0.3828	−0.39
Grip grid latency (s)	32.7 ± 34.9	79.7 ± 101.7	0.1763	−0.18
Rotarod + Grip grid (s)	138.5 ± 61.4	160.4 ± 171.4	0.7027	−0.63
Activity wheels (km/d)	0.32 ± 0.21	0.19 ± 0.33	0.3600	−0.46
Open field distance (m)	12.6 ± 8.1	9.8 ± 5.7	0.4299	0.20
Open field crossings	65.6 ± 49.3	47.3 ± 29.7	0.3908	0.22
Open field rearings	39.8 ± 27.4	30.0 ± 27.2	0.4683	0.33
Open field velocity (cm/s)	11.1 ± 1.2	10.7 ± 2.1	0.5717	0.04

A * indicates p < 0.05.