FIGURE 6.

Analysis of BBB opening and acoustic emissions in wild‐type and APP23 mice. (a) Blood–brain barrier (BBB) of WT and APP23 (APP) mice in response to SUS + MB in one hemisphere was visualized by uptake of fluorescently labeled 10 kDa dextran. (b) Quantification of fluorescence in the SUS^+MB treated hemisphere compared to the untreated hemisphere reveals a similar fold‐change. (c) Acoustic emissions recorded from WT and APP23 mice recorded reveals an increased higher‐harmonic emission, but similar ultra‐harmonic and broadband emission in APP23 mice compared to WT mice. Scale bar (a): 1 cm