TABLE 1.
Top 50 differentially expressed genes in XO4+ microglia between SUS+MB versus sham‐treated APP23 mice
| Gene symbol | logFC | AvgExp | t | Pval | adj PVal | B |
|---|---|---|---|---|---|---|
| Birc5 | 5.76502 | 1.7672889 | 9.02935 | 2.22E‐10 | 3.14E‐07 | 13.48506 |
| Cdkn3 | 5.64183 | 1.5432145 | 6.744088 | 1.18E‐07 | 3.49E‐05 | 7.515466 |
| Kif11 | 5.49926 | 0.2461131 | 6.576116 | 1.91E‐07 | 5.14E‐05 | 6.97426 |
| Ncapg | 5.47342 | −0.1786981 | 5.464827 | 4.88E‐06 | 5.93E‐04 | 3.988828 |
| Cdc20 | 5.45743 | 1.0739871 | 7.403038 | 1.82E‐08 | 8.52E‐06 | 9.133173 |
| Nuf2 | 5.32476 | −0.3289444 | 6.736156 | 1.21E‐07 | 3.49E‐05 | 7.284114 |
| Ccnb2 | 5.2893 | 1.9141487 | 7.553196 | 1.19E‐08 | 6.74E‐06 | 9.804982 |
| Aurkb | 5.28106 | 0.1698159 | 7.026936 | 5.26E‐08 | 2.05E‐05 | 8.075848 |
| Cit | 5.24623 | 0.3082589 | 6.415315 | 3.04E‐07 | 7.16E‐05 | 6.501784 |
| Hmmr | 5.22306 | 1.186993 | 7.569951 | 1.14E‐08 | 6.74E‐06 | 9.797002 |
| Esco2 | 5.20983 | 1.0709507 | 4.81764 | 3.25E‐05 | 2.80E‐03 | 2.353105 |
| Melk | 5.17911 | −0.554891 | 6.172445 | 6.16E‐07 | 1.18E‐04 | 5.824797 |
| Cdc25c | 5.17482 | −0.7504202 | 5.556821 | 3.73E‐06 | 4.68E‐04 | 4.188965 |
| Kif23 | 5.13702 | 0.6650897 | 6.945323 | 6.63E‐08 | 2.30E‐05 | 7.956364 |
| Nek2 | 5.09204 | −0.8391415 | 5.851377 | 1.57E‐06 | 2.54E‐04 | 4.972077 |
| Troap | 5.07497 | −1.0475974 | 7.38968 | 1.89E‐08 | 8.52E‐06 | 8.82398 |
| Dlgap5 | 5.0637 | −0.3794831 | 6.798489 | 1.01E‐07 | 3.16E‐05 | 7.445236 |
| Tk1 | 5.06171 | 1.4926731 | 7.504487 | 1.37E‐08 | 7.36E‐06 | 9.280781 |
| Mcm10 | 5.04637 | −1.0895909 | 7.260236 | 2.71E‐08 | 1.10E‐05 | 8.355957 |
| Saa3 | 4.93308 | −1.1465763 | 5.045849 | 1.67E‐05 | 1.68E‐03 | 2.844773 |
| Plac8 | 4.9074 | 1.316802 | 5.889764 | 1.40E‐06 | 2.33E‐04 | 5.218269 |
| Clspn | 4.87938 | 1.3914605 | 6.258953 | 4.79E‐07 | 9.81E‐05 | 6.258822 |
| Mki67 | 4.81598 | 2.6575306 | 7.401992 | 1.82E‐08 | 8.52E‐06 | 9.451222 |
| Cenpk | 4.81418 | 1.0168275 | 6.273493 | 4.59E‐07 | 9.60E‐05 | 6.240974 |
| Casc5 | 4.79524 | 1.9047316 | 6.021465 | 9.56E‐07 | 1.71E‐04 | 5.65795 |
| Ccnb1 | 4.78376 | 0.8942972 | 8.35344 | 1.33E‐09 | 1.33E‐06 | 11.79537 |
| Ndc80 | 4.77516 | 0.9359373 | 6.74738 | 1.17E‐07 | 3.49E‐05 | 7.549301 |
| Aspm | 4.77431 | 0.7784471 | 6.30262 | 4.22E‐07 | 8.98E‐05 | 6.4019 |
| Mns1 | 4.77059 | −0.9456452 | 5.116901 | 1.35E‐05 | 1.40E‐03 | 2.98948 |
| Stil | 4.71375 | −0.4286108 | 6.896241 | 7.63E‐08 | 2.46E‐05 | 7.747276 |
| Ankle1 | 4.70824 | −0.8978755 | 5.791278 | 1.87E‐06 | 2.91E‐04 | 4.711205 |
| Spc24 | 4.69279 | 1.3423116 | 8.911432 | 3.03E‐10 | 3.80E‐07 | 12.94538 |
| Gpsm2 | 4.65782 | −0.7681863 | 5.503262 | 4.36E‐06 | 5.35E‐04 | 4.048151 |
| Prc1 | 4.6556 | 2.8666675 | 9.092631 | 1.89E‐10 | 3.04E‐07 | 13.79044 |
| Cenpi | 4.63601 | 0.7782963 | 5.284361 | 8.29E‐06 | 9.00E‐04 | 3.53967 |
| Rab13 | 4.6245 | −0.436683 | 5.777597 | 1.95E‐06 | 2.91E‐04 | 4.733482 |
| Cep55 | 4.61759 | 0.1648057 | 6.537217 | 2.14E‐07 | 5.62E‐05 | 6.96793 |
| Hist1h2ae | 4.61674 | 0.6086809 | 5.236377 | 9.54E‐06 | 1.03E‐03 | 3.448414 |
| Cdc6 | 4.59923 | −0.7363785 | 5.380778 | 6.25E‐06 | 7.20E‐04 | 3.650384 |
| Foxm1 | 4.57058 | 0.2001768 | 4.66003 | 5.15E‐05 | 4.18E‐03 | 1.887387 |
| Sgol2a | 4.56722 | 0.8256839 | 5.301333 | 7.89E‐06 | 8.65E‐04 | 3.661214 |
| Tpx2 | 4.5441 | 1.3968306 | 6.899334 | 7.56E‐08 | 2.46E‐05 | 8.057218 |
| Shcbp1 | 4.5333 | −0.2503641 | 6.219989 | 5.36E‐07 | 1.06E‐04 | 6.048152 |
| Chaf1a | 4.5075 | −0.3486608 | 4.197819 | 1.95E‐04 | 1.29E‐02 | 0.699981 |
| Sgol1 | 4.50239 | 1.1036653 | 6.068962 | 8.32E‐07 | 1.54E‐04 | 5.751895 |
| Ckap2l | 4.49338 | 2.7278769 | 7.949218 | 3.99E‐09 | 3.22E‐06 | 10.8567 |
| Rad51ap1 | 4.43737 | 1.7528958 | 5.761704 | 2.04E‐06 | 3.00E‐04 | 4.897387 |
| C330027C09Rik | 4.41274 | 1.2903056 | 4.872646 | 2.77E‐05 | 2.50E‐03 | 2.500517 |
| Ccnf | 4.38312 | 0.9642677 | 5.68638 | 2.55E‐06 | 3.43E‐04 | 4.605822 |
| Ckap2 | 4.37671 | 0.4264924 | 5.925534 | 1.26E‐06 | 2.20E‐04 | 5.33635 |
Note: The logFC changes are reflected by a colour gradient ranging from red (high), to yellow (intermediate) expression.