FIGURE 1.

Polymersomes as platforms for MP study and drug discovery. Polymersomes, which are made up of block copolymers, can mimic biological membranes for reconstitution or incorporation of MPs, including channels, receptors, and protein complexes to form proteopolymersomes (center). Proteopolymersomes can be used to study the structure–function relationship of MPs including the characterization of (a) receptor‐ligand binding through the use of surface plasmon resonance (SPR), ³³ (b) channel transport function through conducting fluorescent dye leakage assay, and (c) MP structure by nuclear magnetic resonance (NMR).Source: Figure 1c is reproduced with permission from reference 34, Copyright 2018, Springer Nature. (d) Proteopolymersomes can also be used in high‐throughput screening (HTS) for drug discovery to identify modulators of MPs. Schematics were created with BioRender.com.