Table 5.

Tests of mediation of cumulative adversity scale on change in DNAm age from childhood to adulthood

	Association with cumulative adversity			Association with change in DNAm age			Bootstrapped Indirect effect
	Coeff.	95% CI	P	Coeff.	95% CI	P	Coeff.	95% CI	P
Psychiatric symptoms
Depression sx.	0.25	0.17–0.33	<0.001	0.29	0.07–0.51	0.009	0.07	0.02–0.13	0.02
Anxiety sx.	0.28	0.14–0.43	<0.001	0.05	−0.08–0.18	0.46	0.01	−0.02–0.05	0.48
Behavioral sx.	0.54	0.33–0.76	<0.001	−0.05	−0.13–0.04	0.25	−0.03	−0.08–0.03	0.27

N=381. Med = mediator. Mediation was tested by a series of linear regression models.