TABLE 1.
Basal cytokine release and response to LPS by preterm, term, and adult monocytes
| Cytokine | Preterm monocytes (n = 14)
|
Term monocytes (n = 16)
|
Adult monocytes (n = 12)
|
|||
|---|---|---|---|---|---|---|
| Basal releasea | LPS-stimulated releaseb | Basal release | LPS-stimulated release | Basal release | LPS-stimulated release | |
| TNF-α | 26.4 ± 9.2 | 3.5 (2.7–7.6) | 22.6 ± 8.2 | 8.2 (4.4–28.4) | 26.2 ± 11.8 | 22.7 (13.7–46.6) |
| IL-6 | 87.5 ± 26.7 | 13.7 (2.7–22.3) | 96.1 ± 37.7 | 13.7 (2.75–22.3) | 13.2 ± 5.6 | 192.8 (11.6–518.2) |
| IL-10 | 1.26 ± 0.71 | 16.5 (4.25–196) | 6.68 ± 2.81c | 29.7 (9.4–36.8) | 22.8 ± 11.9c | 224 (71.3–339.2) |
| IL-8 | 1,413 ± 473 | 4.97 (2.5–6.5) | 3,732 ± 1,060 | 4.4 (2.05–9.1) | 5,075 ± 2,185 | 6.3 (3.6–15.4) |
a
Data are expressed as picograms per 105 cells (mean ± SEM).
b
Fold stimulation by LPS (100 ng/ml) compared to medium control, expressed as the median with the 25th to 75th percentiles in parentheses.
c
P < 0.05 versus preterm cells.