Table 4.

The regulation of pyroptosis on the chondrocytes in the process of bone loss

Target of action	Intervention	Mechanism	Experimental models	Effect	Diseases	References
NF-κB signaling	Loganin	Loganin/NF-κB/NLRP3/caspase-1	Mice	Inhibited bone loss	Osteoarthritis	[138]
NF-κB signaling	Morroniside	morroniside /NF-κB/NLRP3/caspase-1	Mice	Inhibited bone loss	Osteoarthritis	[139]
NF-κB signaling	Nrf2/HO-1	Licochalcone A /Nrf2/HO-1/NF-κB/LPS/NLRP3	Mice and osteoarthritis chondrocytes	Inhibited bone loss	Osteoarthritis	[140]
NF-κB signaling	MicroRNA-326 delivered by BMSC-derived exosomes	microRNA-326 NF-κB/NLRP3	Osteoarthritis chondrocytes	Inhibited bone loss	Osteoarthritis	[141]
NF-κB/NLRP3 crosstalk	P2X7	P2X7/NF-κB/NLRP3 crosstalk	Osteoarthritis chondrocytes	Promoted bone loss	Osteoarthritis	[142]
NLRP3	Ca 2 +	ASIC1a/ Ca 2 + /NLRP3	Adjuvant arthritis rats	Promoted bone loss	Rheumatoid arthritis	[143]
NLRP3	Icariin	Icariin/NLRP3/caspase-1	Chondrocytes and mice	Inhibited bone loss	Osteoarthritis	[144]