Table 6.
The regulation of pyroptosis on other cells in the process of bone loss
| Target of action | Intervention | Mechanism | Experimental models | Effect | Diseases | References |
|---|---|---|---|---|---|---|
| ROS | Bisphenol A | ROS/NLRP3/caspase-1 | MLO-Y4 cells | Promoted bone loss | Not given | [155] |
| NLRP3 and caspase3 | LPS the NF-κB signaling | NLRP3/caspase-1/GSDMD and caspase-3/gasdermin E | fibroblast-like synoviocytes | Promoted bone loss | Rheumatoid arthritis | [156] |
| AIM2 | IFN-γ | IFN-γ/AIM2/caspase-1/ IL-1β and IL-18 | Cholesteatoma tissue | Promoted bone loss | Cholesteatoma | [157] |