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. 2022 Aug 23;30(1):22–37. doi: 10.1038/s41417-022-00515-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The number of CD68+ and CD206+ cells in centre of the tumour (CT) and invasive margin (IM) sections of gastric cancer tissues in gastric cancer patients (n = 241) with different CDK5RAP3 expression levels. Data are presented as the mean ± SD and were analysed using Student’s t-test. B Kaplan–Meier analysis of RFS and OS in gastric cancer patients based on the expression of CDK5RAP3 in gastric cancer (n = 241). C Multiplex fluorescent immunohistochemistry of gastric cancer tissues. CKpan, DAPI, CD68, INOS, CD206 and CDK5RAP3. Scale bar = 100 μm. D Merged fluorescent immunohistochemical images showing the expression of CD206 and INOS in gastric cancer tissues with different expression levels of CDK5RAP3. Scale bar = 100 μm. E In 140 random fields of view, the number of tumour-associated macrophages (TAMs) subgroups with different expression levels of CDK5RAP3 is presented in the scatter plot. Error bars indicate estimated 95% CI (mean ± SD, n = 140). *P < 0.05; **P < 0.01; ***P < 0.001. P-values for all survival analyses were calculated using the log-rank test.