Table 1.
Sequence and inhibitory activity of selected ACE2 epitopes and peptidomimetics.a
Entry | Sequence/Structure | Yield, % | % inhib. at 30 μM |
---|---|---|---|
1 | H-HEAEDLFYQ-NH2 | 28 | 20 |
2 | Ac-HEAEDLFYQ-NH2 | 39 | 12 |
3 | ![]() |
46 | 6 |
4 | ![]() |
12 | 30 |
5 | ![]() |
35 | 8 |
6 | ![]() |
15 | 55 (21 ± 7 μM)b |
Mean from three different assays, errors were in the range of 5–10% of the reported values.
IC50 value was retrieved from dose-response assays as the concentration of compound required for 50% inhibition and estimated by non-linear correlation using GraphPad Prism software.