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. 2023 Jan 16;6:52. doi: 10.1038/s42003-023-04454-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Schematic of the docking interactions between murine c-Fos complex without DNA (PDB code: 2WT7) and DHA. DHA binds murine c-Fos protein, stabilize the interaction by forming a hydrogen bond with Arg 158. b The interaction between the murine c-Fos and DHA (3D) without DNA. c Schematic of the interactions between murine c-Fos and DHA with DNA complex (PDB code: 2WT7). DHA not only binds to mouse c-Fos protein, stabilizes the interaction by forming a hydrogen bond with the 158th Arg but also binds to DNA (the 5th G). d The interaction between murine c-Fos with DNA complex in the presence of DHA (3D). e Schematic of the docking interactions between human c-Fos complex without DNA (PDB code: 1FOS) and DHA. DHA binds c-Jun protein, stabilizes the interaction by forming a hydrogen bond with Lys 282. f The interaction between human c-Fos complex and DHA without DNA (3D). g Schematic of the docking interactions between human c-Fos-c-Jun with DNA complex (PDB code: 1FOS) and DHA. DHA not only binds to human c-Fos protein, stabilizes the interaction by forming a hydrogen bond with the 158th Arg residue but also binds to DNA at the thirty-first adenine position. h The interaction between human c-Fos-c-Jun with DNA complex and DHA (3D). The error bars indicate standard error.