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. 2023 Jan 17;9:6. doi: 10.1038/s41421-022-00490-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of the overall experimental procedure. The cardiac IVS tissues of HCM patients who underwent surgical myectomy were collected for snRNA-seq (n = 10; 10 samples) and spatial transcriptomic assays (n = 6; 8 tissue sections). As a control, cardiac IVS tissues from healthy heart transplant donors (n = 2; 3 samples; the samples HEALTHY1A and HEALTHY1B were from the same donor) were subjected to snRNA-seq. b Unbiased clustering of 55,122 nuclei from all 13 samples identifies 9 major cell types. The nucleus count is indicated by the number in parenthesis. c UMAP plot showing the expression of the established marker genes for each cell type. d Comparison of the nucleus densities in the UMAP space between the two conditions reveals remarkable changes in the relative proportion of cell types in HCM. Nuclei were randomly sampled in equal numbers for each group (n = 15,939). e Relative proportion of each cell type in each condition. +: expansion; –: contraction. f Heatmap showing the molecular signature of each lineage. CM cardiomyocyte, FB fibroblast, lEC lymphatic endothelial cell, SMC smooth muscle cell, vEC vascular endothelial cell.