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. 2023 Jan 17;9:6. doi: 10.1038/s41421-022-00490-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a H&E staining image for the cardiac tissue section HCM1225D. b Masson’s trichrome staining image of a section adjacent to HCM1225D. c UMAP plot showing the spot clusters identified using unbiased clustering of the spots on HCM1225D. d Distribution of the spot clusters on the HCM1225D section. e Spatial location of the subpopulations FB1, FB2, CM1, and CM2 on the HCM1225D section predicted by integrating snRNA-seq data and spatial transcriptomic data. f Expression distribution of representative markers and candidate target genes on the section HCM1225D. g Dysregulated pathways in fibrotic versus non-fibrotic regions of the cardiac tissue sections of HCM. The dysregulated pathways were identified based on the pathway activity scores of each spot using the Wilcoxon rank-sum test. The significance threshold was set to a Bonferroni-adjusted P-value < 0.05 and an absolute of the log2 fold change > 0.25. HCM1220B and HCM1220C are sections from different samples of the same patient; HCM1406B and HCM1406C are neighboring sections from the same patient. h Activity of representative upregulated pathways in fibrotic regions on the HCM1225D section.