FIG. 5.

Effect of Ad-5/IL-10 on A. pleuropneumoniae-induced lung pathology. Pigs were treated as described in the legend to Fig. 4, and pathological changes were assessed. (A) Gross lung lesions were scored on a scale from 1 to 4 as described in Materials and Methods. (B) Relative %L/B. (C) Lung lavage fluid samples were analyzed for MPO activity with tetramethylbenzidine substrate. Data represent median (bar) and minimum and maximum (circles) of each group (A) or means ± standard deviations (error bars) of triplicate determinations (B and C) from eight control animals (not infected with A. pleuropneumoniae), five A. pleuropneumoniae-infected animals (APP), or three A. pleuropneumoniae-infected animals pretreated with Ad-5/IL-10 (APP + IL-10).