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. 2023 Jan 16;14:239. doi: 10.1038/s41467-023-35854-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cryo-electron micrograph of hnRNPDL-2 filaments. Representative image from 1114 micrographs. The inset shows a representative reference-free 2D class average image of the hnRNPDL-2 filament. Scale bar, 50 nm. b Side view of the three-dimensional cryo-EM density map showing the structured core of an individual hnRNPDL-2 filament. The fibril pitch is indicated. c Detailed view of the cryo-EM density map showing the layer packing in the hnRNPDL-2 filament (left panel). The filament rise/subunit is indicated in Å. Rendered side view of the secondary structure elements accounting for three stacked rungs comprising residues N226-D276 (right panel). The distance between the stacks is indicated in Å. d Sequence of hnRNPDL exon 6, according to hnRNPDL-2 numbering. The observed β-strands that build the hnRNPDL-2 fibrils amyloid core are indicated. e Cryo-EM density map of a layer of hnRNPDL-2 amyloid core. Fitting of the atomic model for residues N226-D276 is shown on top. D259 disease-associated amino acid is highlighted in red. Water molecules are shown as red spheres. f Representative 3D class average image of the hnRNPDL-2 amyloid fibril.