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. 2023 Jan 16;13:854. doi: 10.1038/s41598-023-27859-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Uterine epithelial-specific deletion of Gp130 confers female infertility. (a) Pregnancy outcomes in the control and epithelial-specific deletion of Gp130 (Gp130 ecKO) females. Gp130 ecKO females are completely infertile even though they all mated with a wildtype male. (b) Representative uteri from control and Gp130 ecKO females on D5. Implantation sites (red arrows), which are visualized by a blue dye injection in the control, are not seen in Gp130 ecKO. Unimplanted blastocysts were recovered from Gp130 ecKO uteri. (c) Serum levels of progesterone (P4) and 17β-estradiol (E2) at D4. (d) Representative pictures showing the gross morphology of artificial decidualization (4 days after oil injection) from control and Gp130 ecKO. Red arrow indicates the site of sesame oil injection. (e) The ratio between the wet weight of the oil-injected (stimulated) horn and that of the unstimulated horn was calculated. Scale bar, 1 cm.