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Imetelstat effects on cigarette smoke-induced small airway remodeling. Representative lung tissue sections of mice exposed to air or cigarette-smoke (CS) with or without Imetelstat, and stained for HE, picrosirius red, α-SMA, or PAS (a). Quantification of small airways wall thickness [mean in (b), distribution in (c)], α-SMA expression (d), PAS staining (e). Original magnification, ×20. n = 7–8 mice per group. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01.
