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. 2023 Jan 16;13:25. doi: 10.1038/s41598-022-25993-7

Figure 4.

Figure 4

Effects of TA-65 on TGF-β-induced fibroblasts-to-myofibobroblasts differentiation in vitro. Mouse primary lung fibroblasts (MPLF) and MEF cells were pre-treated with TA-65 (2 µM) or Imetelstat (1 µM) during 24 h, followed by TGF-β treatment (10 ng/mL) for 48 h. Histograms show quantification of α-SMA expression evaluated by immunostaining (a: MPLF; b: MEF). Representative images of cells stained with α-SMA monoclonal antibody are available in Supplementary Fig. S3. n = 3 samples per group. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01.