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Effects of TA-65 on TGF-β1-induced ROS production in vitro. Mouse primary lung fibroblasts (MPLF) and MEF cells were pre-treated with TA-65 (2 µM) or Imetelstat (1 µM) during 24 h, followed by TGF-β treatment (10 ng/mL) for 48 h. Quantification of intracellular reactive oxygen species (ROS) production by measuring H2-DCFH-DA (2,7-dichlorofluorescein diacetate) oxidation in MPLF (a) and MEF (b). n = 3–4 samples per group. Data are presented as mean ± SEM. *p < 0.05.
