Table 4.

Application of drugs targeting phosphorylation modification in autophagy-related diseases

Drugs targeting phosphorylation modification	Target	Disease types	Autophagy activation or inhibition	Drug effect on diseases	Relevant mechanism
SBI-0206965	ULK1	Tumor	Activation	Tumor suppression²²¹	ULK1-Beclin1/VPS34
WX8 and SB202190	PIKfyve kinase and p38MAPK	Tumor	Inhibition	Tumor suppression²²²	LAMP2 phosphorylation↓
Ibrutinib	SRMS	Tumor	Activation	Tumor suppression²²³	SRMS-FKBP51-AKT
Salidroside	PI3K	Tumor	Activation	Tumor suppression²²⁴	PI3K-AKT-mTOR
Fasudil	–	Traumatic urethral stricture	Inhibition	Injury alleviation²²⁵	AKT-mTOR
KYP-2047	PREP	Parkinson’s disease	Activation	Injury alleviation²²⁶	PP2A-DAPK1-Beclin1
Exendin-4	GLP1R	Type 2 diabetes	Activation	Pancreatic β cells survival²²⁷	RAPGEF4/EPAC2--PPP3/calcineurin-TFEB
Trehalose	–	Neurodegeneration	Activation	Neurodegeneration amelioration²²⁸	PPP3/calcineurin-TFEB