TABLE 1.
ALDHs as potential diagnostic markers in non‐tumor diseases
| ALDH isoenzymes | Disease | Ref. |
|---|---|---|
| ALDH1A1 | Cataract formation, Parkinson's disease, Alzheimer's disease | 52 , 54 , 55 , 57 , 58 , 59 |
| ALDH1A2 | Congenital heart disease, congenital anomaly syndrome | 61 , 62 |
| ALDH1B1 | Alcohol‐induced hypersensitivity, diabetes | 24 , 64 , 65 |
| ALDH2 | Alcohol intolerance, hypertension, liver cirrhosis, Alzheimer's disease, Parkinson's disease, coronary heart disease, myocardial infarction | 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 |
| ALDH3A1 | Cataract formation | 84 |
| ALDH3A2 | Sjögren–Larsson syndrome | 86 |
| ALDH4A1 | Hyperprolinemia type II, schizophrenia, atherosclerosis | 81 , 82 |
| ALDH5A1 | Succinic semialdehyde dehydrogenase deficiency | 87 |
| ALDH6A1 | Methylmalonic academia | 88 |
| ALDH7A1 | Pyridoxine‐dependent epilepsy, osteoporosis | 89 , 90 |
| ALDH16A1 | Gout; Mast syndrome | 91 , 92 |
| ALDH18A1 | Cutis laxa (CL) syndromes, hyperammonemia | 93 , 94 |