Fig. 4.

Primarily female Fabry rats display reduced locomotion, self-care, and exploration while increasing time spent sleeping. Sleeping (A), twitching/foraging group (B), locomotion/self-care group (C), and exploratory group (D) defined by hierarchacal clustering. Fraction of time spent for each behavior group (average of days 1–2). Data normalized to the minimum and maximum means for each behavior group is plotted in a radial graph for both female (E) and male (F) rats. Mean behaviors are normalized and plotted. N = 10 wt-Male, 10 KO-Male, 11 wt-Female, 10 Het-Female, and 9 KO-Female. *p < 0.05.