Table 2. Metabolic pathway analysis for the siBMP5-2 group compared with the siNC group.
| Pathway | Totala | Hitsb | Raw P valuec | Holm adjust P valued | Impact valuee |
|---|---|---|---|---|---|
| Glycerophospholipid metabolism | 36 | 4 | <0.001 | <0.001 | 0.26 |
| Linoleic acid metabolism | 5 | 1 | 0.022 | 1.00 | <0.01 |
| alpha-Linolenic acid metabolism | 13 | 1 | 0.057 | 1.00 | <0.01 |
| GPI-anchor biosynthesis | 14 | 1 | 0.062 | 1.00 | <0.01 |
| Glycerolipid metabolism | 16 | 1 | 0.070 | 1.00 | 0.01 |
| Arachidonic acid metabolism | 36 | 1 | 0.152 | 1.00 | <0.01 |
a, total is the total numbers of compounds in the pathway. b, hits represents the number of metabolites that matched with the metabolites of the HMDB based on the accurate mass of each MF that differed significantly (adjusted P<0.05 and |log2(FC)| >0.58) in siBMP5 vs. siNC groups. c, the original P value calculated from the over-representation analysis. d, the P value adjusted by Holm-Bonferroni method. e, the impact value is calculated from the pathway topology analysis. GPI, glycosylphosphatidylinositol; HMDB, Human Metabolome Database; MF, metabolomic features.