Table 2. Adverse events above grade III related to drug treatment.

First author	Adverse event	Incidence of grade 3 or higher AE (95% CI)	Risk ratio (95% CI)
Cloughesy TF	Hepatitis	0.43 (0.30–0.62)	50.59 (32.01–80.31)
Zhao J	Lipase increased	0.71 (0.51–0.98)	42.01 (28.37–61.82)
Nduom EK	GGT increased	0.47 (0.30–0.69)	41.96 (25.27–66.53)
Schalper KA	Type 1 diabetes	0.18 (0.10–0.30)	41.86 (20.20–84.44)
Du Four S	Colitis	0.47 (0.34–0.65)	37.90 (25.49–56.49)
Jan CI	Increased transaminases	0.13 (0.05–0.27)	34.21 (12.46–84.56)

AE, adverse event; CI, confidence interval; GGT, gamma-glutamyltransferase.