FIG. 1.
Comparison of different CNF1-positive UPEC strains in the C3H/HeOuJ mouse model of ascending UTI. Ten female C3H/HeOuJ mice per bacterial strain were inoculated with 1.0 × 108 CFU and sacrificed 3 days later. Urine, bladders, and kidneys were collected and homogenized, and serial dilutions were plated for colony counts. (A) Bacterial counts in urine. (B) Bacterial counts in bladders. (C) Bacterial counts in kidneys. Each point represents one sample. The height of the bar represents the mean for those samples. In all cases except C189 in the bladder, the counts for J96 were significantly lower than those of CP9, C85, and C189 (analysis of variance, P < 0.0001, followed by Student's t test, P < 0.05).