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. 2022 Dec;10(24):1380. doi: 10.21037/atm-22-6104

Figure 3.

Figure 3

M2-TAMs significantly promoted the invasion and migration of LUAD cells, both in vitro and in vivo. (A) Matrigel invasion assay and crystal violet staining of LUAD cells A549 and H1975 in M2-TAMs co-culture group or control group, n=3. (B) Wound scrape assay and bright field images of LUAD cells A549 and H1975 in M2-TAMs co-culture group or control group, n=3. (C) Mouse models of lung metastases formation via tail vein injection. (D)Number of lung metastasis node in mice, n=5. (E) Representative HE staining slices of lung and mediastinal tissues from mice with lung metastases. Data were presented as mean ± SEM, ***P<0.001, and ****P<0.0001 according to two-tailed independent t-test. M2-TAMs, M2 phenotype tumor-associated macrophages; LUAD, lung adenocarcinoma.