Table 3.

The top enriched pathways by up-and downregulated pathways

ID	Pathways	Gene No	P value	Genes
hsa04657	IL-17 signaling pathway	14	<0.001	JUN, CXCL8, CCL20, CXCL1, FOS, CXCL3, PTGS2, CXCL2, MMP9, NFKBIA, IL1B, FOSB, S100A9, S100A8
hsa04668	TNF signaling pathway	11	<0.001	NFKBIA, JUN, EDN1, CCL20, IL1B, CXCL1, FOS, CXCL3, PTGS2, CXCL2, MMP9
hsa04620	Toll-like receptor signaling pathway	9	<0.001	NFKBIA, JUN, CXCL8, IL1B, CCL4, CCL3, CD14, FOS, TLR2
hsa04625	C-type lectin receptor signaling pathway	9	<0.001	NFKBIA, JUN, CLEC4D, EGR3, FCER1G, IL1B, NLRP3, CLEC4E, PTGS2
hsa05323	Rheumatoid arthritis	5	<0.001	JUN, CXCL8, CCL20, IL1B, CCL3, CXCL1, FOS, TLR2