Table 2.
Clinical and biochemical variables according to steatosis grade of 490 T2DM patients
| Continuous variables | Steatosis grade | P | |||
|---|---|---|---|---|---|
|
| |||||
| S0 (<248) n=94 | S1 (248 to <268) n=41 | S2 (268 to <280) n=29 | S3 (≥280) n=326 | ||
| Age, years | 49.6 (8.2) | 49.6 (7.5) | 49.6 (8.7) | 50.1 (7.1) | 0.926 |
| Systolic blood pressure, mmHg | 125.3 (16.1) | 125.7 (16.0) | 125.6 (16.0) | 131.8 (16.6) | 0.001 |
| Diastolic blood pressure, mmHg | 74.0 (11.2) | 75.9 (11.4) | 75.1 (12.8) | 76.2 (9.9) | 0.402 |
| BMI, kg/m2 | 30.5 (6.6) | 32.5 (4.1) | 32.0 (4.9) | 33.4 (5.6) | 0.001 |
| Waist circumference, cm | 102.2 (12.4) | 103.1 (11.2) | 103.0 (10.8) | 107.3 (12.3) | 0.001 |
| Waist/hip ratio | 0.95 (0.1) | 0.95 (0.08) | 0.92 (0.09) | 0.97 (0.08) | 0.075 |
| ALT, IU/L | 23.7 (23.1) | 19.7 (7.7) | 22.4 (13.4) | 28.5 (17.9) | 0.005 |
| AST, IU/L | 20.7 (14.4) | 17.8 (5.0) | 20.4 (8.6) | 22.9 (14.5) | 0.132 |
| GGT, IU/L | 43.2 (75.7) | 31.5 (37.8) | 26.1 (16.3) | 37.1 (52.8) | 0.547 |
| Serum bilirubin, µmol/L | 8.9 (4.4) | 9.2 (5.8) | 9.5 (6.8) | 9.0 (10.2) | 0.985 |
| Alkaline phosphatase, IU/L | 77.7 (39.9) | 72.2 (18.5) | 74.6 (16.8) | 75.3 (24.0) | 0.733 |
| Serum albumin, g/L | 41.4 (3.1) | 41.2 (2.4) | 41.1 (2.6) | 41.8 (2.7) | 0.265 |
| Fasting blood glucose, mmol/L | 9.0 (3.7) | 8.0 (3.4) | 7.9 (2.7) | 9.0 (3.5) | 0.174 |
| HbA1c, % | 8.1 (2.0) | 8.1 (2.1) | 8.1 (1.8) | 8.4 (1.9) | 0.320 |
| Total cholesterol, mmol/L | 4.3 (1.2) | 4.3 (1.2) | 4.4 (1.0) | 4.4 (1.1) | 0.960 |
| HDL-cholesterol, mmol/L | 1.2 (0.5) | 1.2 (0.3) | 1.2 (0.4) | 1.0 (0.3) | <0.001 |
| LDL-cholesterol, mmol/L | 2.7 (0.9) | 2.7 (1.0) | 2.7 (0.9) | 2.7 (0.9) | 0.884 |
| Triglycerides, mmol/L | 1.4 (0.7) | 1.4 (0.8) | 1.6 (0.8) | 1.8 (1.5) | 0.057 |
| Elasticity, kPa | 5.5 (4.5) | 4.6 (2.1) | 4.8 (1.7) | 5.9 (4.8) | 0.176 |
Values are expressed as mean (standard deviation or SD), Test used: one-way analysis of variation (ANOVA) BMI: body mass index, ALT: alanine aminotransferase, AST: aspartate aminotransferase, GGT: γ-glutamyl transpeptidase, HDL: high-density lipoprotein, LDL: low-density lipoprotein.