Table 4.
Clinical and biochemical variables according to fibrosis grade of 396 T2DM patients
| Parameters | Fibrosis stage | ANOVA P | |||
|---|---|---|---|---|---|
|
| |||||
| F0-F1 n=361 | F2 n=3 | F3 n=16 | F4 n=16 | ||
| Age, years | 49.9±7.3 | 44.0±15.1 | 52.0±5.8 | 50.9±5.6 | 0.321 |
| Systolic blood pressure, mmHg | 129.8±16.5 | 134.0±2.8 | 134.8±13.7 | 144.6±17.6 | 0.004a |
| Diastolic blood pressure, mmHg | 75.9±10.3 | 77.0±5.7 | 75.4±10.3 | 78.3±10.6 | 0.831 |
| BMI, kg/m2 | 32.7±4.8 | 39.9±11.5 | 38.4±9.5 | 36.1±8.1 | <0.001b |
| Waist circumference, cm | 105.6±11.3 | 118.8±10.9 | 121.8±24.9 | 115.2±20.9 | <0.001c |
| Waist/hip ratio | 0.96±0.08 | 0.99±0.06 | 0.96±0.08 | 0.98±0.09 | 0.655 |
| ALT, IU/L | 26.77±16.9 | 25.0±10.8 | 28.6±21.9 | 35.3±17.3 | 0.273 |
| AST, IU/L | 21.8±13.1 | 20.3±5.9 | 26.5±21.9 | 26.1±13.5 | 0.381 |
| GGT, IU/L | 34.8±51.3 | 20.5±0.7 | 38.6±19.4 | 56.4±40.9 | 0.408 |
| Serum bilirubin, µmol/L | 9.1±10.0 | 8.5±3.9 | 8.5±3.9 | 8.5±3.8 | 0.989 |
| Alkaline phosphatase, IU/L | 74.3±23.1 | 77.0±8.2 | 82.4±22.9 | 80.8±24.2 | 0.392 |
| Serum albumin, g/L | 41.8±2.7 | 41.1±1.1 | 40.4±2.8 | 40.9±2.0 | 0.145 |
| Fasting blood glucose, mmol/L | 8.7±3.2 | 8.5±3.4 | 10.9±4.6 | 8.9±3.9 | 0.083 |
| HbA1c, % | 8.3±1.9 | 7.6±0.9 | 9.1±2.3 | 8.4±1.8 | 0.425 |
| Total cholesterol, mmol/L | 4.3±1.1 | 5.4±1.4 | 4.5±0.8 | 4.3±1.1 | 0.372 |
| HDL-cholesterol, mmol/L | 1.1±0.3 | 0.8±0.1 | 1.1±0.2 | 1.0±0.2 | 0.299 |
| LDL-cholesterol, mmol/L | 3.1±7.1 | 3.8±1.5 | 2.8±0.6 | 2.6±0.9 | 0.989 |
| Triglycerides, mmol/L | 1.7±1.5 | 2.5±1.3 | 1.7±0.9 | 1.7±0.8 | 0.824 |
| CAP, dB/m | 318.5±40.4 | 342.0±30.5 | 352.6±36.6 | 346.9±44.2 | 0.001d |
Post hoc analysis: a - Significant difference between F0F1 and F4 (P=0.003); b - Significant difference between F0F1 and F3 (P<0.001); c - Significant differences between F0F1 and F3 (P<0.001) and F0F1 and F4 (P=0.026); d - Significant difference between F0F1 and F3 (P=0.06) and between F0F1 and F4 (P=0.049). BMI: body mass index, ALT: alanine aminotransferase, AST: Aspartate aminotransferase, GGT: γ-glutamyl transpeptidase, HDL: high-density lipoprotein, LDL: low-density lipoprotein, CAP: Controlled attenuation parameter.