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Scheme representing the effect of ACY‐1215 on JAK2 signalling downstream EPO‐R activation. (A) Without ACY‐1215, 14‐3‐3ζ/LNK interactions release JAK2 from the negative control mediated by LNK on its activation and signalization. (B) In the presence of ACY‐1215, hyperacetylation of 14‐3‐3ζ blocks 14‐3‐3ζ/LNK interaction, increasing the LNK fraction that can interact with and inhibit JAK2.
