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. 2023 Jan 10;4:e42700. doi: 10.2196/42700

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©Ashutosh Kumar, Adil Asghar, Himanshu N Singh, Muneeb A Faiq, Sujeet Kumar, Ravi K Narayan, Gopichand Kumar, Prakhar Dwivedi, Chetan Sahni, Rakesh K Jha, Maheswari Kulandhasamy, Pranav Prasoon, Kishore Sesham, Kamla Kant, Sada N Pandey. Originally published in JMIR Bioinformatics and Biotechnology (https://bioinform.jmir.org), 10.01.2023.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Bioinformatics and Biotechnology, is properly cited. The complete bibliographic information, a link to the original publication on https://bioinform.jmir.org/, as well as this copyright and license information must be included.

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The mutational landscape in SARS-CoV-2 variant B.1.1.529 (Omicron, sublineage: BA.1). The analysis of the mutations present at the RBD using a deep mutational scanning pipeline by Starr et al [21] reflected prominent ACE2-binding affinity and protein expression changes (see Table 1). Notably, mutations decreasing the ACE2-binding affinity and protein expression were significantly greater in number. ACE2: angiotensin-converting enzyme 2; ORF: open reading frame; RBD: receptor-binding domain; RBM: receptor-binding motif.