Table 4.

Mutations in SARS-CoV-2 variant B.1.1.529 (Omicron, sublineage BA.1) spike protein influencing viral oligomerization interfaces.^a

Mutations	Frequency (%)b	Remarks	Reference
S371L	0.00	N/Ac	[16,21]
S373P	0.01	N/A	[16,21]
S375F	0.00	N/A	[16,27]
K417N	0.83	N/A	[16,21,28]
S477N	1.31	S477N was also resistant to neutralization by the human convalescent sera tested in this study, but not to vaccine-elicited sera	[16,21,29]
Q493R	0.01	N/A	[30,31]
N501Y	24.11	Associated with increased transmissibility and increased affinity for human ACE2d receptor	[16,21,28,32]
Y505H	0.00	N/A	[16,21]
N764K	0.01	N/A	[16]
D796Y	0.08	N/A	[16]
N856K	0.00	N/A	[16]
Q954H	0.00	N/A	[16,40]
N969K	0.00	N/A	[16]
L981F	0.00	N/A	[16]

^aBased on the genomic sequences of Omicron uploaded on GISAID [16] (last date of collection December 10, 2021).

^bAmong all SARS-CoV-2 genomic sequences uploaded on GISAID [16].

^cN/A: not applicable.

^dACE2: angiotensin-converting enzyme 2.