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SARS-CoV-2 Mpro function, cleavage sites, and structure. (A) Cartoon representation of the Mpro and PLpro cleavage sites in viral polyproteins. (B) Sequence alignment of the 11 cleavage sites of Mpro. (C) X-ray crystal structure SARS-CoV-2 Mpro with nirmatrelvir (PDB: 7SI9). (D) X-ray crystal structure of SARS-CoV-2 Mpro C145A mutant with the peptide substrate SAVLQSGF (PDB: 7MGS). Figure (A) was created with Biorender.com.
