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SARS-CoV-2 Mpro inhibitors identified from screening a protease inhibitor library. X-ray crystal structures of SARS-CoV-2 Mpro with GC376 (PDB: 6WTT) (A), calpain inhibitor II (PDB: 6XA4) (B), calpain inhibitor XII (PDB: 6XFN) (C), and boceprevir (PDB: 6XQU) (D). (E) Chemical structures of GC376, calpain inhibitors II and XII, and boceprevir and their enzymatic inhibitory activity against SARS-CoV-2 Mpro and host cathepsin L. N.T. = not tested.
