Fig. 1.

Chronic Unpredictable Mild Stress and Biochemical Assessments. A) The schematic for CUMS in which mice underwent 1-month of chronic stress. Behavioral tests were completed the last 2 weeks of stress and included both memory and anxiety-like assessments. B) Morris Water Maze showed no significant differences between non-stressed and CUMS conditions with no significant changes between sexes. C) Open Field test showed that both conditions, both sexes overwhelming preferred the periphery over the center area. CUMS females significantly preferred the periphery more than CUMS males. D) Corticosterone concentration in non-stressed and CUMS APP mice divided by sex in pg/mL. Stress increased corticosterone expression and females of both conditions had higher overall expression than their male counterparts. All data is presented as Mean ± SEM, n = 8–10 per group in B and C, n = 5–7 in D, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.