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. 2022 Dec 31;27(4):423–435. doi: 10.3746/pnf.2022.27.4.423

Fig. 2.

Fig. 2

Effects of NaticolⓇ on skin wrinkle-related factors, TGF-β R1 (A), procollagen type І (B), collagen type І (C), protein band (D), p-JNK (E), p-c-FOS (F), p-c-Jun (G), MMP-1 (H), MMP-3 (I), MMP-9 (J), and p-Smad3 (K), in Hs27 cells exposed to UVB. Cells were treated with UVB (50 mJ/cm2), except NC, and incubated for 24 h with 100 µg/mL of L-ascorbic acid (PC) and various concentrations (100, 200, and 400 µg/mL) of NaticolⓇ collagen. Values are presented as mean±SD. Different letters (a-f) represent significant differences at P<0.05, as determined by Duncan’s multiple range test. The biomarkers used for Western blot analysis are listed in Table 1. The primers used for gene expression analysis are listed in Table 2. NC, normal control; C, control; PC, positive control; UVB, ultraviolet B.