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. 2022 Dec 31;27(4):423–435. doi: 10.3746/pnf.2022.27.4.423

Fig. 6.

Fig. 6

Effects of NaticolⓇ on skin wrinkle-related factors, TGFbR1 (A), procollagen type І (B), collagen type І (C), protein band (D), p-JNK (E), p-c-FOS (F), p-c-Jun (G), MMP-1 (H), MMP-3 (I), MMP-9 (J), and p-Smad3 (K), in the dorsal skin of SKH-I hairless mice exposed to UVB. NC, AIN93G; C, UVB irradiation+AIN93G; PC1, UVB irradiation+AIN93G with L-ascorbic acid (100 mg/kg); PC2, UVB irradiation+AIN93G with arbutin (100 mg/kg); NaticolⓇ150, UVB irradiation+AIN93G with NaticolⓇ collagen (150 mg/kg); NaticolⓇ300, UVB irradiation+AIN93G with NaticolⓇ collagen (300 mg/kg). Values are presented as mean±SD. Different letters (a-f) represent significant differences at P<0.05, as determined by Duncan’s multiple range test. Biomarkers used for Western blot analysis are listed in Table 1. Primers used for gene expression analysis are listed in Table 2. NC, normal control; C, control; PC, positive control; UVB, ultraviolet B.