Fig. 4.

Effect of Pluchea indica leaf extract (PIE) on relative weight of epididymal fat tissue (A), the average size of adipocytes (B), and histological pictures of adipocytes (C) in high fat-high fructose diet (HFFD) rats. Epididymal adipose tissue was stained using H&E (magnification: 100×). Data are presented as mean± SEM (n=6 per group). *P<0.05 when compared with the normal diet (ND) group and ^#P<0.05 when compared with the HFFD group. BW, body weight; HFFD+PIE 100 or 300, HFFD rats+PIE 100 or 300 mg/kg/d; HFFD+PIO, HFFD rats+pioglitazone 10 mg/kg/d.